摘要
结肠癌是世界范围内最常见的恶性肿瘤之一,其常规治疗手段在为患者提供生存益处的同时,副作用和局限性也不容忽视.中药因其多靶点、多途径、毒副作用较小的抗肿瘤优势备受国内外学者关注.不少中药及从中提取的以黄酮类、酚类、生物碱为代表的中药有效成分在抗肿瘤方面发挥了有效作用,其机制与抑制肿瘤细胞增殖、诱导细胞凋亡、调控自噬、抑制肿瘤细胞侵袭和转移、抑制肿瘤血管生成等有关.本文就近年来中药有效成分抑制结肠癌机制研究进行梳理,以期为中药应用于结肠癌的临床治疗提供参考.
Abstract
Colon cancer is one of the most common malignant tumors worldwide.When the conventional treatment methods provide survival benefits for patients,their side effects and limitations cannot be ignored.Many traditional Chinese medicines has attracted much attention from scholars at home and abroad because of its anti-tumor advantages of multi-target,multi-pathway and less toxic side effects.Many Chinese medicines and the active components extracted from them,represented by flavonoids,phenols and alkaloids,have played an effective role in anti-tumor.There mechanism is related to inhibiting tumor cell proliferation,inducing apoptosis,regulate autophagy,inhibiting tumor cell invasion and metastasis,inhibiting tumor angiogenesis.In this paper,the mechanism of inhibiting colon cancer by effective components of traditional Chinese medicine in recent years was reviewed in order to provide reference for the clinical treatment of colon cancer.
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