首页|基于"脾虚邪滞"理论探讨胃解痉多肽表达化生中医病机与微观辨证

基于"脾虚邪滞"理论探讨胃解痉多肽表达化生中医病机与微观辨证

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胃癌前病变(Gastric precancerous lesions,GPL)具有发展为胃癌的风险,而胃解痉多肽表达化生(Spasmolytic polypeptide expressing metaplasia,SPEM)是GPL的初始步骤,具有恶性进展为胃癌前病变的风险。目前关于该化生阶段发病机制的探讨尚不完整,中医药依托扎实的中医理论基础及丰富的中药资源,在防治GPL上具有独特优势。因此,笔者基于"脾虚邪滞"理论,从疾病的病理生理状态、标志物、信号通路三方面进行微观辨证分析,提出以健脾化瘀解毒法为主要疗法,结合文献分析其可行性,以期为SPEM的中医治疗提供新的思路与方法。
Discussion on the Pathogenesis and Microcosmic Syndrome Differentiation of Spasmolytic Polypeptide Expressing Metaplasia Based on the Theory of"Spleen Deficiency and Evil Stagnation"
Gastric Precancerous Lesions(GPL)have the risk of developing gastric cancer,and Spasmolytic Polypeptide Expressing Metaplasia(SPEM)is the initial step of GPL,which has the risk of malignant progression to gastric precancerous lesions.Currently,the exploration of the pathogenesis during this metaplasia stage remains incomplete.Traditional Chinese Medicine(TCM),relying on its solid theoretical foundation and abundant resources of Chinese medicinal materials,possesses unique advantages in the prevention and treatment of GPL.Based on the theory of"spleen deficiency and evil stagnation",we conducts microcosmic syndrome differentiation analysis from the pathophysiological state,markers,and signal pathways of the disease,and proposes to invigorate the spleen and remove blood stasis.The detoxification method is used for treatment,and its feasibility is analyzed in combination with the literature,in order to provide new ideas and strategies for the TCM treatment of SPEM.

Spasmolytic Polypeptide Expressing MetaplasiaMicrocosmic syndrome differentiationGastric precancerous lesionsJianpi huayu jiedu therapy

李新龙、李思怡、杨鹏辉、李秋月、潘华峰

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广州中医药大学科技创新中心 广州 510006

广州中医药大学脾胃研究所 广州 510006

深圳市龙华区人民医院 深圳 518109

广州中医药大学临床药理研究所 广州 510006

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胃解痉多肽表达化生 微观辨证 胃癌前病变 健脾化瘀解毒法

国家自然自然科学基金委员会面上项目广东省科学技术厅广东省重点领域研发计划项目中国博士后科学基金会面上项目

821743192020B11111000112023M740859

2024

世界科学技术-中医药现代化
中科院科技政策与管理科学研究所,中国高技术产业发展促进会

世界科学技术-中医药现代化

CSTPCD北大核心
影响因子:1.175
ISSN:1674-3849
年,卷(期):2024.26(5)
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