摘要
多糖是中药主要活性成分,其结构多样、活性丰富且毒性低,是理想的新药研发原料.研究表明中药多糖在抗肿瘤、免疫调节、抗纤维化及抗阿尔茨海默病等关联活性中表现突出,具有明确的作用机制与靶向性.本文综述着重讨论了中药多糖在抗肿瘤、免疫调节、肠道菌群调节、抗纤维化和治疗阿尔茨海默病方面的作用机制和靶标分子发现研究进展.通过对文献分析,发现中药多糖的作用机制呈现出多样性和复杂性,特别是在免疫调节、抗肿瘤和血管新生抑制等方面表现出显著的靶向性.同时,本综述对目前中药多糖研究存在的不足和面临的挑战进行了总结和分析,并提出了未来研究的方向,旨在为理解中药活性物质基础及多糖类原创新药研发提供新思路和策略.
Abstract
Polysaccharides are the main active ingredients in traditional Chinese medicine and ideal raw materials for new drug development with diverse structures,rich activity and low toxicity.Research has shown that traditional Chinese medicine polysaccharides(TCMP)exhibit outstanding associated activities in anti-tumor,immunomodulatory,anti-fibrotic,and Alzheimer's disease prevention,with clear mechanisms and targeting properties.In this review,we discuss research progress of the mechanisms and discovery of target molecules of TCMP in various areas,including anticancer,immunomodulation,gut microbiota regulation,anti-fibrosis,and Alzheimer's disease prevention.By analyzing relevant literature,it has been observed that TCMP exhibits various complex mechanisms of action,highlighting significant targeting properties in immunomodulation,anticancer effects and disrupts angiogenesis activities.At the same time,this review summarizes and analyzes the current shortcomings and challenges in the research on TCMP and proposes future directions,aiming to provide new ideas and strategies for understanding the basis of active substances in traditional Chinese medicine and the development of original new drugs based on polysaccharides.
基金项目
国家自然科学基金委员会面上项目(31870801)
中山市科学技术局中山市科研团队项目(CXTD2022012)
国家科技期刊平台
NSTL
万方数据