中药复方基于细胞信号通路防治2型糖尿病的研究进展
Research Progress of Traditional Chinese Medicine Compound in Prevention and Treatment of Type 2 Diabetes Based on Cell Signaling Pathway
彭川 1冉思燕 1何苗 1陈正涛 2胡玉立 3李梅 4吴丽丽 5秦灵灵 6刘铜华7
作者信息
- 1. 达州市中心医院康复医学科 达州 636500
- 2. 江西中医药大学附属医院 南昌 330006
- 3. 北京中医药大学深圳医院 深圳 518172
- 4. 北京中医药大学生命科学院 北京 100029
- 5. 北京中医药大学中医学院 北京 100029
- 6. 北京中医药大学教育部中医养生学重点实验室 北京 100029
- 7. 北京中医药大学中医学院 北京 100029;北京中医药大学教育部中医养生学重点实验室 北京 100029
- 折叠
摘要
2型糖尿病作为一种慢性代谢性疾病,随着发病率的不断增加,给人类健康造成极大的威胁.越来越多的研究证实,糖尿病的发病机制与多种细胞信号通路的改变密切相关.虽然有大量研究报道中药复方通过调控细胞信号通路防治糖尿病,但对其调控细胞信号通路的作用机制尚缺乏系统完善的综述.鉴于此,本文通过综合近几年国内外文献,对中药复方基于细胞信号通路防治2型糖尿病的研究进行归纳总结,发现主要与PI3K/AKT、AMPK、MAPK、NF-κB、Nrf2/ARE、PPAR、TGF-β等信号通路有关,此系列信号通路能够通过抑制胰岛细胞凋亡、保护胰岛β细胞功能、改善胰岛素抵抗、抑制肝脏糖异生、促进糖原合成、减轻炎症反应、抗氧化应激等来治疗2型糖尿病,同时分析当前研究存在的问题以及未来发展趋势,以期为中药复方防治糖尿病的药物开发与临床应用提供科学的理论基础.
Abstract
As a chronic metabolic disease,type 2 diabetes poses a significant threat to human health with increasing incidence.An increasing number of studies confirm that the pathogenesis of diabetes is closely related with alterations in multiple cellular signaling pathways.Although numerous studies have reported that traditional Chinese medicine compounds prevent diabetes by modulating cell signaling pathways,asystematic review of the mechanism of action of traditional Chinese medicine compounds in modulating cell signaling pathways is still lacking.Therefore,this paper summarizes the research of type 2 diabetes prevention and treatment,which was found mainly related to the signaling pathways such as PI3K/AKT,AMPK,MAPK,NF-κB,PPAR,TGF-β.This family of signaling pathways can treat type 2 diabetes by inhibiting pancreatic islet cell apoptosis,protecting pancreatic β-cell function,ameliorating insulin resistance,inhibiting hepatic gluconeogenesis,promoting glycogen synthesis,attenuating inflammation,and resisting oxidative stress.At the same time,we analyze the problems in current research and the future development trend,in order to provide a scientific theoretical basis for the drug development and clinical application of traditional Chinese medicine compound in the prevention and treatment of diabetes.
关键词
2型糖尿病/中药复方/细胞信号通路/研究进展Key words
Type 2 diabetes/Compound Chinese medicine/cell signaling pathway/research progress引用本文复制引用
基金项目
北京中医药大学横向课题(1130065120002)
出版年
2024
NETL
NSTL
万方数据