Research Developments of Classic Famous Prescription:Wendan Decoction and its Prediction Analysis of Q-marker
The Wendan Decoction,a classic prescription first recorded in Yao Shengyuan's"Ji Yan Fang"during the Southern and Northern Dynasties,has been a mainstay in Traditional Chinese Medicine(TCM)clinical applications.Recently included in the first batch of the"Catalogue of Ancient Classical Famous Prescriptions"and highlighted in the"Key Information List of Ancient Classical Famous Prescriptions(25 Prescriptions)",this paper summarizes the research progress on Wendan Decoction.The decoction is recognized for its lipid-lowering,blood pressure-reducing,anti-inflammatory,and anti-schizophrenic properties,and is extensively used in modern clinical practice,especially for neurological,cardiovascular,digestive,and endocrine system disorders.In TCM,Wendan Decoction is often tailored and applied in cases diagnosed with phlegm and stasis.Referencing the"Q-marker"quality standard proposed by Academician Liu Changxiao in 2016,this study predicts the quality markers of Wendan Decoction based on the"five principles",identifying β-sitosterol,succinic acid,quercetin,tricin,luteolin,naringin,nobiletin,hesperidin,naringenin,6-gingerol,glycyrrhizin,and glycyrrhetinic acid as key constituents.These findings are intended to facilitate the refinement of Wendan Decoction's prescription and enhance its clinical effectiveness.
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