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音乐干预肺癌相关焦虑抑郁结局指标及评价工具的现状分析

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目的 分析音乐干预肺癌相关焦虑抑郁的随机对照试验(Randomized controlled trial,RCT)中结局指标及评价工具的使用情况。方法 检索9个数据库,按照纳入排除标准筛选文献,随后汇总结局指标,按照结局指标的属性进行分类、使用频次频率统计分析。结果 共检索到243篇文献,最终纳入18篇文献。按照结局指标的功能属性,将其分为 8 个指标域:焦虑状态评分量表(24。19%)、抑郁状态评分量表(16。13%)、生活质量评分量表(14。52%)、睡眠质量评分量表(9。68%)、疼痛评分量表(4。84%)、血生化指标(14。52%)、生命体征(11。29%)、肺及运动功能指标(FEV1%、6MWD、BODE指数)(4。84%)。纳入的RCTs整体偏倚风险较高;疗程长短不一导致测量时间不同;音乐干预形式呈多样性;他评量表及客观指标使用较少;忽视安全性指标;评价工具方法较单一;部分RCTs未明确分级标准。结论 目前音乐干预肺癌相关焦虑抑郁的RCTs结局指标使用尚存在一定缺陷,影响了试验的可信度,建议规范化使用结局指标,建立音乐干预肺癌焦虑抑郁临床研究的核心指标集。
Current Analysis of Outcome Indicators and Evaluation Tools in Music Interventions for Lung Cancer-Related Anxiety and Depression
Objective To analyze the use of outcome indicators and evaluation tools in randomized controlled trial(RCT)of music interventions for lung cancer-related anxiety and depression.Methods Nine databases were searched,and the literature was screened according to inclusion and exclusion criteria,followed by a summary of outcome indicators,and statistical analysis of classification and frequency of use according to the attributes of the outcome indicators.Results A total of 243 articles were retrieved,and 18 RCTs were finally included.The outcome indicators were classified into 8 indicator categories according to their functional attributes:anxiety scale(24.19%),depression scale(16.13%),quality of life scale(14.52%),sleep quality scale(9.68%),pain scale(4.84%),blood biochemical indicators(14.52%),vital signs(11.29%),and pulmonary and exercise function indicators(FEV1%,6MWD,BODE index)(4.84%).The problems are as follows:First,the overall risk of bias is high in the included RCTs.Second,the timing of measurement is variable due to inconsistency in the length of treatment.Third,the forms of music intervention are diverse.Besides,the use of other rating scales and objective indicators is low and safety indicators were neglected.Finally,the method of evaluation tools was single and some RCTs did not specify grading criteria.Conclusion The use of outcome indicators and evaluation tools in music interventions for lung cancer-related anxiety and depression has certain shortcomings,which affects the credibility of the trials.It is recommended to standardize the use of outcome indicators and establish a core set of indicators for clinical studies of music intervention for lung cancer-related anxiety and depression.

MusicLung cancerAnxietyDepressionOutcome indicators

戴悦宁、焦丽静、孙晨冰、龚亚斌、许玲

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上海中医药大学附属岳阳中西医结合医院 上海 200437

上海中医药大学附属岳阳中西医结合医院肿瘤转化研究所 上海 200437

音乐 肺癌 焦虑 抑郁 结局指标

2024

世界科学技术-中医药现代化
中科院科技政策与管理科学研究所,中国高技术产业发展促进会

世界科学技术-中医药现代化

CSTPCD北大核心
影响因子:1.175
ISSN:1674-3849
年,卷(期):2024.26(7)