谷氨酸受体介导的中枢神经突触可塑性改变及针刺调节机制研究进展
Research Progress on Glutamate Receptor-Mediated Changes in Synaptic Plasticity of Central Nervous System and Acupuncture Regulation Mechanism
王觉 1刘安国 1马重兵 1贾静 1张倩 1严兴科1
作者信息
- 1. 甘肃中医药大学针灸推拿学院 兰州 730101
- 折叠
摘要
突触是神经元之间信息传递的关键部位,具有一定的可塑性.谷氨酸受体(GluRs)在中枢神经系统的突触可塑性中发挥重要作用,而针刺能够调节病理状态下的GluRs趋于正常,其研究也在不断深入.本文总结了近年来关于离子型谷氨酸受体(iGluRs)和代谢型谷氨酸受体(mGluRs)两种类型的谷氨酸受体对突触可塑性的影响以及针刺对iGluRs和mGluRs表达调节作用的研究文献,以期基于GluRs的表达为针刺调节神经突触可塑性提供理论依据,并为后续研究提供借鉴.
Abstract
Synapse is the key part of information transmission between neurons,which has certain plasticity.Glutamate receptor plays an important role in the synaptic plasticity of the central nervous system,and acupuncture can regulate the glutamate receptor to normal under pathological conditions,and its research is also deepening.This paper summarizes the recent research literature on the effects of two types of glutamate receptors,ionic glutamate receptor and metabotropic glutamate receptor,on synaptic plasticity,as well as acupuncture regulating the expression of ionic glutamate receptor and metabotropic glutamate receptor,in order to provide a theoretical basis for acupuncture regulating synaptic plasticity based on glutamate receptor expression,and provide reference for subsequent research.
关键词
针刺/谷氨酸受体/突触可塑性/调节作用Key words
Acupuncture/Glutamate receptor/Synaptic plasticity/Regulating effect引用本文复制引用
出版年
2024
国家科技期刊平台
NSTL
万方数据