目的 系统梳理细胞自噬与中药源性肝损伤的相互作用和肝损伤发生机制，并就中药源性肝损伤防治策略进行总结。方法 基于中国知网、万方、PubMed、Web of Science数据库的检索，查阅近十年内关于细胞自噬及中药源性肝损伤相关文献，阐明细胞自噬与疾病发生间的关系，归纳细胞自噬引起中药源性肝损伤的常见药物及作用机制，总结中药源性肝损伤的防治策略。结果 细胞自噬在中药源性肝损伤的发生发展中具有双重调控作用，细胞自噬在过分活跃或过度抑制的情况下可通过影响自噬通路或自噬相关分子的表达，诱发中药源性肝损伤。结论 细胞自噬通路的调控，有望成为防治中药源性肝损伤的新途径，针对性的制定防治策略是实现中草药安全性风险监测的重要措施。
Research Progress of the Dual Role of Autophagy in Herb-Induced Liver Injury and its Prevention and Treatment Strategies
Objective This article systematically reviews the interaction between autophagy and herb-induced liver injury,and it elucidates the mechanism of liver injury.Also,it summarizes the control strategies of herb-induced liver injury.Methods Based on the retrieval of CNKI,Wanfang,PubMed and Web-of-Science databases,the literature on autophagy and herb-induced liver injury in the past decade was reviewed to clarify the relationship between autophagy and disease occurrence.Then we summarize common drugs and the mechanism of herb-induced liver injury caused by autophagy.The control strategies of herb-induced liver injury were summarized,too.Results Autophagy plays a dual role in the herb-induced liver injury.Autophagy pathway and autophagy-related molecules can be changed in the case of excessive activation or excessive inhibition to cause herb-induced liver injury.Conclusion The regulation of autophagy pathway is expected to be a new method for the prevention and treatment of herb-induced liver injury.Targeted control strategies are important measures to realize the safety risk monitoring of Chinese herbal medicine.
万方数据
