An Overview of the Emotional Pathogenesis of MCI and the Cognitive Neuropsychological Research Ideas of MCI Caused by the Constitution of Qi-Stagnation
Mild cognitive impairment(MCI)between normal brain aging and senile dementia is recognized as a key window to delay the progression of cognitive decline to dementia or even reverse to normal brain aging.Enlightening and delaying aging,protecting the brain and preventing aging,and maintaining health before illness are the dominant areas of the physique theory of traditional Chinese medicine,among which the constitution of Qi-stagnation with long-term emotional disorder is closely related to the occurrence,development and deterioration of MCI,which may be one of the prone physique of MCI.So far,there is no recognized and high-quality evidence to report the characteristic components of the early stage of cognitive decline.Recent studies have shown that the impairment of cognitive flexibility of one of the core components of brain cognitive control occurs in the earlier stage of cognitive decline,it may be an early specific sensitive index of MCI.This paper preliminarily combs the etiology and pathogenesis of MCI with long-term dysphoria and stagnation of liver-qi,hyperactivity of liver-qi and weakness of liver-qi,and puts forward the research idea of using neuropsychological scale combined with modern cognitive neuroscience techniques such as event-related potentials,functional magnetic resonance imaging,eye movement and near-infrared spectroscopy imaging to investigate the acceleration of brain aging caused by long-term emotional disturbance and qi depression in multi-angle,omni-directional and three-dimensional way.The purpose of this study is to provide theoretical reference for the study of emotional etiology and pathogenesis in MCI,and to provide new perspectives,methods and ideas for the treatment of diseases with excessive cognitive decline from the perspective of liver visceral manifestations and the constitution of traditional Chinese medicine.
Mild cognitive impairmentCognitive flexibilityConstitution of Qi-stagnationEvent-related potentials(ERPs)Functional magnetic resonance imaging(fMRI)Eye trackingFunctional near-infrared spectroscopy(fNIRS)
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