Efficacy and Safety of Chinese Herbal Medicine Bai-Tou-Weng-Tang Combined with Amino Salicylic Acid for the Treatment of Ulcerative Colitis:A Meta-Analysis of a Randomized Controlled Trials
Objective Ulcerative colitis(UC)is a chronic inflammatory bowel disease with a prolonged course and no cure.The purpose of this study was to systematically evaluate the clinical effect and safety of Bai-tou-weng-tang(BTW)combined with amino salicylic acid(ASA)in the treatment of UC.Methods The relevant Chinese and English databases were searched,and the eligible literatures were screened using inclusion and exclusion criteria and evaluated for quality.Relative risk(RRs),weight mean differences(WMDs)and 95％confidence intervals(CIs)were used to evaluate the clinical effect,safety and other indicators of different drugs for UC.Sensitivity analysis and publication bias were used to evaluate the stability of the results.Results A total of 61 clinical studies were included,involving 5483 patients with UC.The results of meta-analysis showed that BTW combined with ASA not only had better cure rate(RR=1.85,95％CI:1.62-2.10)and total efficiency rate(RR=1.23,95％CI:1.19-1.26),but also could reduce the incidence of adverse reactions(RR=0.61,95％CI:0.42 to 0.89)and recurrence rate(RR=0.33,95％CI:0.20 to 0.57).In addition,BTW combined with ASA had better efficacy in improving patients'syndrome,disease severity,intestinal mucosal score under colonoscopy,histopathological score and quality of life.Finally,BTW combined with ASA can regulate the levels of serum inflammatory factors and immunological indexes after treatment.Conclusion BTW combined with ASA can not only improve the clinical effect of UC patients,but also improve safety,which may be a new way to treat UC.
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