目的 评价目前针灸治疗骨质疏松症(Osteoporosis,OP)动物实验的报告质量,以期为今后的相关研究提供参考.方法 在中国知网、万方、维普、PubMed、Web of Science和Embase六个数据库进行文献检索,检索时间截止2022年12月31日.对检索的文献进行去重、题目及摘要初筛和全文复筛后,使用ARRIVE指南和SYRCLE偏倚评价工具对纳入的文献进行质量评价.结果 初检文献共643篇,最终纳入136篇文献进行质量评估.评价发现:针灸治疗OP动物实验的报告质量整体较为均衡,文章总评分呈现缓慢波动上升趋势,目前研究存在的问题集中于纳排标准的设置、随机化与盲法的实施、伦理声明与动物护理的缺失以及实验实施具体细节的不清晰等方面,这些问题带来的选择偏倚、实施偏倚、报告偏倚是影响文献评分的关键因素.结论 当前针灸治疗OP的动物实验研究在方法学上存在设计不严谨、实施不透明、报告不规范等问题,建议未来的研究借助SYRCLE偏倚评价工具及ARRIVE指南完善实验的设计思路,改进实施与报告的规范性,进而提高针灸治疗OP动物实验相关结果的严谨性与可信度,以促进针灸治疗OP的临床推广.
Evaluation of Quality of Animal Experiment Reports on Acupuncture Therapy for Osteoporosis Based on ARRIVE Guidelines and SYRCLE Risk Assessment Tool
Objective To evaluate the quality of animal experiment reports on the treatment of Osteoporosis(OP)by acupuncture therapy,furtherly provide reference for future research.Methods Literature search was conducted in six databases,including China National Knowledge Infrastructure(CNKI),Wanfang,VIP,PubMed,Web of Science and Embase from inception to December 31,2022.After removing duplicates,title and abstract preliminary screening and full text re-screening,the included literatures were involved for quality evaluation according to ARRIVE guidelines and SYRCLE risk assessment tool.Results 643 literatures were initially examined and 136 were included for quality assessment.The evaluation results showed that the reports quality is relatively balanced on the whole,and score of the articles showed a slow fluctuation and upward trend.The current existing problems focus on the settings of the inclusion and exclusion standard,implementation of randomization and blindness,lack of ethical statements and animal care,and unclear report of experiment details,etc.The selection bias,implementation bias and reporting bias are negative factors which drag down essay ratings.Conclusion Current animal experiments on acupuncture therapy treatment of OP still existed some methodological problems including imrigorous design,opaque implementation and non-standard reporting.It is suggested that future researches should improve the design,implementation and reporting of experiments with the help of SYRCLE risk assessment tool and ARRIVE guideline,so as to improve the rigor and credibility of animal experimental results and promote the clinical promotion of acupuncture treatment for OP.
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