Application Status and Prospect of Metabolomics in the Diagnosis of Henoch-Schonlein Purpura
Objective To explore the clinical significance of metabolomics and its metabolites in the diagnosis and treatment of Henoch-Schonlein purpura(HSP).Methods Through literature search,the changes of metabolites in blood,urine and feces of HSP patients and animal models and their clinical significance were summarized.Results A total of 22 HSP-related differential metabolites were summarized,including lipids,unsaturated fatty acids,amino acids,nucleotides and organic acids.Conclusions Differential metabolites are expected to become new metabolic markers for the diagnosis of HSP and its prognosis analysis.In addition,in terms of treatment,correcting metabolic abnormalities may become a new strategy for the treatment of HSP in the future.
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