The incidence of depression is increasing year by year,seriously affecting people's work and life.With the continuous in-depth study of its pathogenesis,it is found that depression is closely related to intestinal flora.The imbalance of intestinal flora can cause central nervous system diseases through the microbial-brain-gut axis,which involves neurotransmitters,neuroendocrine,neurotrophic factors,inflammatory response and other mechanisms.This paper introduced intestinal flora and relevant regulatory factors related to various mechanisms of depression,listed experimental examples of intestinal flora imbalance leading to depression,and then summarized relevant studies on the anti-depression mechanism of traditional Chinese medicine through regulation of intestinal flora according to the mechanism of action,among which the regulation of microbial metabolism,inflammatory factors and neurotransmitters was mainly studied.The conclusion is expected to provide some reference for the study of anti-depression effect of Chinese medicine.
万方数据