针灸常用于类风湿性关节炎(Rheumatoid arthritis,RA)的临床治疗.但其作用机制不清.DNA传感通过环磷酸鸟苷-腺苷合酶(Cyclic GMP-AMP synthase,cGAS)/干扰素基因刺激因子(Stimulator of interferon genes,STING)途径激活先天免疫,诱导炎症反应.同时,STING介导的Ⅰ型干扰素(Type-Ⅰinterferons,IFNs-Ⅰ)信号被证明是伤害性感受的关键调控分子,成为RA干预的潜在靶点.本文回顾了cGAS/STING激活和信号转导的分子机制和功能,特别强调了这一信号通路在周围神经系统神经免疫交互中的抗伤害性作用,并设想了针刺改善RA的神经免疫机制研究的新思路,为针刺治疗RA等免疫失常相关的自身免疫疾病提供新的研究方向,并为干预STING途径的临床转化提供新的策略和方法.
Abstract
Acupuncture is often used in the clinical treatment of Rheumatoid arthritis(RA).However,its mechanism of action remains unclear.DNA sensing activates innate immunity and induces inflammatory responses through the cyclic GMP-AMP synthase(cGAS)/stimulator of interferon genes(STING)pathway.Meanwhile,STING mediated type-Ⅰinterferons(IFNs-Ⅰ)signaling has been proved to be a key regulatory molecule of nociception,which has become a potential target for RAtreatment.This article reviews the molecular mechanisms and functions of cGAS/STING activation and signal transduction,with particular emphasis on the antinociception effect of this signaling pathway in neuro-immune interactions in the peripheral nervous system,and envisage new ideas for the study of the neuroimmune mechanism of acupuncture in improving RA,which provides a new research direction for the treatment of RA and other autoimmune diseases related to immune disorders.It also provides new strategies and methods for the clinical transformation of intervention STING pathway.
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