Analysis of an Animal Model of Erectile Dysfunction Based on the Characteristics of Clinical Conditions in Chinese and Western Medicine
Objective Based on the characteristics of erectile dysfunction in Chinese and western medicine,we analyzed the existing animal models and evaluated the clinical match of the models as well as their strengths and weaknesses,with a view to improving the existing animal models and providing a more intuitive reference for clinical research.Methods The existing animal models of erectile dysfunction were searched,categorized,and combined with the clinical characteristics of erectile dysfunction in Chinese and Western medicine,the models were evaluated for their clinical compatibility and their strengths and weaknesses.Results The existing models of erectile dysfunction are divided into vascular models,neurological models,psychological models,detrusor models and endocrine models according to the etiology of the disease,a total of 10 kinds,of which,the higher degree of Chinese medicine clinical match is the drug injection combined with a high-fat diet to replicate the type 2 diabetes mellitus erectile dysfunction animal model,the high uric acid erectile dysfunction rat model,the degree of Chinese medicine match is 63%,and can be comprehensively simulated clinical The higher degree of match in Western medicine is the bilateral cavernous nerve compression model and spinal cord injury model,with the degree of match in Western medicine being 49%;each model has its own advantages and disadvantages,generally due to the lack of a modeling method that combines TCM and Western medicine with disease evidence.Conclusion The existing animal models are prepared with a single causative factor,mostly in accordance with the etiology and mechanism of Western medicine,with less connection to the mechanism of Chinese medicine,and lack of reflection of Chinese medicine symptoms,and the degree of Chinese and Western medicine match is generally not high,Chinese and Western medicine treatment of disease from a multi-faceted diagnosis and treatment should be a combination of the characteristics of Chinese and Western medicine,using multifactorial modeling methods,to reflect the pathology of the pathological process of erectile dysfunction,to improve the existing model,and to establish a more in line with the characteristics of the Chinese and Western medicine clinical conditions of the erectile dysfunction animal models,to provide references for the prevention and control of the clinic.
Erectile dysfunctionImpotencePathological combinationAnimal modelFitAdvantages and disadvantages
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