Analysis of Animal Model of Gastroesophageal Reflux Disease Based on the Combination of Disease and Syndrome
Objective Gastroesophageal reflux disease(GERD)is a condition in which the contents of the stomach break through the anti-reflux barrier and reflux from the stomach into the esophagus and even into the mouth,throat,and airway,causing symptoms or complications,and it is one of the most common intractable diseases of the upper gastrointestinal tract,which seriously affects the quality of life of patients.Traditional Chinese medicine(TCM)is effective and highly accepted in the treatment of GERD,and an animal model that combines disease and syndrome is the basis and prerequisite for conducting relevant research.Methods Relevant databases were searched,and based on the clinical diagnostic criteria of GERD in Chinese and Western medicine,the modeling methods,modeling performance,and modeling characteristics of the existing animal models of GERD combined with disease and syndrome were summarized,and the reasons for the selection of the specific modeling methods and evaluation indexes were explored,and the degree of match was evaluated based on the characteristics of the clinical disease and syndrome in Chinese and Western medicine.Results The combination model of GERD was based on surgical or pharmacological stimulation,such as esophageal instillation of exogenous acid,surgical intervention to change the physiological structure of the gastrointestinal tract of the rat causing gastric reflux or mixed reflux,and imposition of TCM interventions,with chronic unpredictable stimulation for the liver qi depression syndrome type of animal model,with pinch-tail stimulation for the qi-stagnation and phlegm-obstruction type,with chronic stress stimulation in conjunction with a high-fat diet for the blood stasis blocking collaterals type,with internal and external causes of dampness-heat for the splenic-deficiency damp heat syndrome.The intervention method was mainly used.Conclusion The current animal model of GERD has a high degree of consistency with the characteristics of Western medicine,but a lower degree of consistency with Chinese medicine.Therefore,according to the differences in the mechanism of Chinese medicine,we propose corresponding improvements and observation methods,as well as the shortcomings of the current study,in order to provide reference for the establishment of the GERD model,to establish an animal model that conforms to the characteristics of the Western and Eastern medicine and has a high degree of clinical consistency,so as to lay the foundation for the research on the mechanism of GERD and medication.The study will lay the foundation for the research of GERD mechanism and drugs.
Gastroesophageal reflux disease(GERD)Non-erosive reflux disease(NERD)Animal modelsCombination of disease and syndromeModel evaluation
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