首页|基于"脾散精藏意"探讨氨基酸在认知功能障碍中的作用

基于"脾散精藏意"探讨氨基酸在认知功能障碍中的作用

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认知功能障碍归属中医学"呆病""痴证"范畴,发病率逐年升高,调节氨基酸代谢可能是从脾论治认知功能障碍的重要机制。氨基酸为脾所散之精,布周身而司藏意,可作为潜在的生物标志物;氨基酸类神经递质散于脑,传达脾所藏之意,参与神经元通信及认知活动过程。治法以补脾益气、温阳健脾、滋阴补脾为主,兼以化痰祛瘀解毒,以调节氨基酸代谢,恢复脾主运化功能,改善认知功能障碍。在"脾散精藏意"理论指导下调节氨基酸代谢为中医药治疗认知功能障碍疾病提供了新的理论依据及研究策略。
Exploring the Role of Amino Acids in Cognitive Dysfunction Based on"Spleen Governs Dispersing Essence and Storing Meaning"
Cognitive impairment belongs to the categories of"foolish disease"and"delusional syndrome"in traditional Chinese medicine,the incidence rate is increasing year by year,and regulating amino acid metabolism may be an important mechanism for the treatment of cognitive dysfunction from the spleen.Amino acids are the essence dispersed by the spleen,which can be used as potential biomarkers.Amino acid neurotransmitters are scattered in the brain,convey the meaning of the spleen,and participate in neuronal communication and cognitive activities.The treatment method is mainly to nourish the spleen and invigorate qi,warm yang and strengthen the spleen,nourish yin and nourish the spleen,and also dissolve phlegm,dispel stasis and detoxify,so as to regulate amino acid metabolism,restore the main function of the spleen,and improve cognitive dysfunction.Under the guidance of the theory of"spleen governs dispersing essence and storing meaning",the regulation of amino acid metabolism provides a new theoretical basis and research strategy for the treatment of cognitive dysfunction diseases in traditional Chinese medicine.

Spleen governs dispersing essence and storing meaningAmino acidsCognitive impairmentTreatment based on the spleen

李婷婷、战丽彬、范晓凤

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辽宁中医药大学中医脏象理论及应用教育部重点实验室 沈阳 110847

辽宁中医药大学附属医院 沈阳 110032

辽宁省中医脾脏象现代研究重点实验室 沈阳 110847

脾散精藏意 氨基酸 认知功能障碍 从脾论治

2024

世界科学技术-中医药现代化
中科院科技政策与管理科学研究所,中国高技术产业发展促进会

世界科学技术-中医药现代化

CSTPCD北大核心
影响因子:1.175
ISSN:1674-3849
年,卷(期):2024.26(10)