The Theory of"Toxin and Heat"in Acute Pancreatitis Based on the"Microbiota-Metabolism-Immunity"Axis
Patients and animal models suffering from acute pancreatitis(AP)have characteristic phenotypes of gut microbiota,which is associated with the severity of AP.Gut microbiota directly or indirectly participates in host immune regulation by catabolizing nutrients into functional products.The imbalance of gut microbiota and its metabolites activate the immune inflammatory response,which attribute to the aggravation of AP.According to the theory of traditional Chinese medicine,the abnormal metabolism and the release of inflammatory factors caused by the imbalance of gut microbiota are classified into the category of"endotoxin",which combine with external toxins(alcohol,food,cold poisoning,etc.)to turn into heat and even fire.Therefore,"microbiota-metabolism-immunity"axis disorder is the molecular biological basis for the"toxin and heat"theory in AP.For traditional Chinese medicine,classical prescriptions and proven prescriptions could treat AP by targeting to regulate the"microbiota-metabolism-immunity"axis,which not only enriches the"toxic and heat"theory,but also provides new ideas for the prevention of AP.
"Toxin and heat"theoryAcute pancreatitisGut microbiotaMetabolitesHost immunity
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