首页|基于从肝论治的气络调节探讨肠道菌群-胆汁酸轴改善2型糖尿病胰岛素抵抗

基于从肝论治的气络调节探讨肠道菌群-胆汁酸轴改善2型糖尿病胰岛素抵抗

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研究发现,肠道菌群和胆汁酸代谢在2型糖尿病胰岛素抵抗(Type 2 diabetes mellitus-insulin resistance,T2DM-IR)的发生和发展中发挥了重要作用。近年来研究表明,肝失疏泄导致的肝气络形气转化失常是T2DM-IR的病机关键,且与肠道菌群和胆汁酸代谢失调关系密切。本文深入探讨了肠道菌群与胆汁酸代谢在中医从肝论治的气络调节中的重要作用,揭示其对促进胰岛素敏感性提升以及能量代谢平衡的积极影响,为临床治疗2型糖尿病提供参考和借鉴价值。
To Explore the Effect of Gut Microbiota-Bile Acid Axis on Insulin Resistance in Type 2 Diabetes Mellitus Based on Liver-Oriented Therapy with Qi Colligation Regulation
Studies have found that gut microbiota and bile acids metabolism play an important role in the occurrence and development of type 2 diabetes mellitus and insulin resistance(T2DM-IR).Recent studies have shown that the abnormal transformation of qi and Liver-qi collaterals caused by liver dysfunction is the key to the pathogenesis of T2DM-IR,which is closely related to intestinal flora and bile acid metabolism disorders.This article delves into the crucial role of intestinal microbiota and bile acid metabolism in regulating qi and collaterals within traditional Chinese medicine treatment from a hepatic perspective.It unveils its favorable impact on enhancing insulin sensitivity and achieving balance in energy metabolism,thereby offering valuable references for clinical management of T2DM.

Intestinal flora disorderInsulin resistanceType 2 diabetes mellitusBile acid metabolismQi collaterals theory

王宇、宋佳媛、王丽、张乃文、朴春丽

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长春中医药大学中医学院 长春 130000

长春中医药大学中西医结合学院 长春 130000

广州中医药大学深圳医院(福田) 深圳 518000

肠道菌群失调 胰岛素抵抗 2型糖尿病 胆汁酸代谢 气络学说

2024

世界科学技术-中医药现代化
中科院科技政策与管理科学研究所,中国高技术产业发展促进会

世界科学技术-中医药现代化

CSTPCD北大核心
影响因子:1.175
ISSN:1674-3849
年,卷(期):2024.26(11)