Model Study and Comparison of Models for Autoimmune Thyroid Disease and its Complications
Autoimmune thyroid disease(AITD)is a common organ-specific autoimmune disease.The pathological features are significantly increased titers of Thyroglobulin antibody(TgAb)and/or Thyroid peroxidase antibody(TPOAb),accompanied by lymphocyte infiltration in thyroid tissue.The incidence of this disease is increasing year by year,its pathogenesis is complex,and its complications such as Hashimoto's encephalopathy,infertility or abortion,and related nephropathy are harmful.Therefore,this disease has become one of the research hotspots in this field.Animal models play a crucial role in basic disease research.In recent years,many scholars have revealed the etiology,pathogenesis,complications,and therapeutic intervention mechanisms of traditional Chinese and Western medicine through different animal models of AITD.In this paper,animal selection,specific modeling methods and model evaluation of mouse models of AITD and its complications in recent years were summarized and analyzed,so as to provide a reference for the selection of animal models for AITD basic experimental research.
Autoimmune thyroid diseaseComplications of autoimmune thyroid diseaseAnimal modelsModeling method
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