脓毒症是机体对感染的反应失调产生危及生命的器官功能损害疾病，以发热、寒颤、气促、意识改变为特征，甚至出现多器官功能衰竭(Multiple organ dysfunction syndrome，MODS)等严重并发症。该病的发病率和死亡率连年居高，存在医疗资源耗费大、预后不佳等问题，严重影响患者的生存质量和经济负担。因此，探索高效、安全、廉价的新型治疗方法十分重要。本病发病机制复杂，其中炎症反应失衡是脓毒症的主要发病机制。丝裂原活化蛋白激酶(Mitogen-activated protein kinases，MAPK)信号通路是受环境因素或炎症因子等激活的信号通路，介导增殖、分化、炎症反应和凋亡等功能，在脓毒症发生发展中扮演关键角色。目前，抗生素、液体复苏、机械通气是临床上治疗脓毒症的主要方法，虽然能遏制部分病情的进展，但部分治疗效果欠佳。大量文献证实，中医药干预脓毒症具有显著优势，其通过多途径、多靶点调控MAPK信号通路，抑制炎症反应、加强免疫防御而有效治疗脓毒症，是脓毒症目前的研究热点。然而，目前仍缺乏对中医药调控MAPK信号通路治疗脓毒症的系统综述。故本文通过检索近年来国内外数据库脓毒症相关文献，系统性总结MAPK信号通路与脓毒症的关系及中医药在其中的作用，为脓毒症的治疗及开发新药提供新的理论支撑。
Research Progress of Traditional Chinese Medicine Intervention on Sepsis Based on MAPK Signaling Pathway
Sepsis is a life-threatening Organ Dysfunction disease caused by the dysregulated response of the body to infection.It is characterized by fever,chills,shortness of breath,altered consciousness,and even severe complications such as Multiple Organ Dysfunction Syndrome(MODS).The morbidity and mortality of this disease are high year after year,and there are problems such as large consumption of medical resources and poor prognosis,which seriously affect the quality of life and economic burden of patients.Therefore,it is important to explore new treatments with high efficiency,safety and low cost.The disease pathogenesis is complex,including inflammation imbalance is the main pathogenesis of sepsis.Mitogen-Activated Protein Kinases(MAPK)signaling pathway is a signaling pathway activated by environmental factors or inflammatory factors,which mediates proliferation,differentiation,inflammatory response and apoptosis,and plays a key role in the occurrence and development of sepsis.At present,antibiotics,fluid resuscitation and mechanical ventilation are the main methods for clinical treatment of sepsis.Although they can curb the progress of some diseases,some treatment effects are not good.A large amount of literature has confirmed that Chinese medicine intervention in sepsis has significant advantages,its through many channels,regulation and control of multiple targets,MAPK signaling pathways,inhibit inflammation,strengthening immune defense and effective in the treatment of sepsis,sepsis is current research hotspot.However,there is still a lack of systematic reviews on the regulation of MAPK signaling pathway by traditional Chinese medicine in the treatment of sepsis.Therefore,based on the retrieval database sepsis related literature at home and abroad in recent years,a systemic summary of MAPK signal pathway and sepsis relations and the role of traditional Chinese medicine in them,will be new drugs for the treatment of sepsis and development provides new theoretical support.
SepsisMAPK signaling pathwayTraditional Chinese medicineInflammatory factorResearch progress
万方数据
