首页|Efficacy and Safety of Chinese Herbal Medicines Combined with Chemical Drugs for Alzheimer's Disease:A Systematic Review and Meta-Analysis

Efficacy and Safety of Chinese Herbal Medicines Combined with Chemical Drugs for Alzheimer's Disease:A Systematic Review and Meta-Analysis

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  • 国家科技期刊平台
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  • NSTL
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Objective:To evaluate the effcacy and safety of Chinese herbal medicines(CHMs)combined with chemical drugs for the treatment of Alzheimer's disease(AD).Materials and Methods:Databases were searched to retrieve randomized controlled trials(RCTs)of CHMs combined with tacrine,galantamine,rivastigmine,donepezil,or memantine,following strict inclusion and exclusion criteria.Only research papers published in English,Chinese,and Japanese were considered.The primary outcome was the mini-mental state examination(MMSE)score and the secondary outcomes were AD assessment scale cognitive subscale(ADAS-Cog)score and safety evaluation.Meta-analysis was carried out using RevMan 5.3 and subgroup analysis was conducted to identify the sources of heterogeneity.Results:A total of 15 RCTs with 1386 participants were included in this study.Only donepezil was used in the retrieved literature.Meta-analyses showed that the combination of CHMs with donepezil led to significant improvement in the MMSE score(Z=9.45;P<0.00001;weighted mean difference[WMD]=2.68,95%confidence interval[CI]:2.12-3.24)and a significant decrease in the ADAS-Cog score(Z=5.53;P<0.00001;WMD =-3.79;95%CI:-5.13--2.44).Safety evaluation demonstrated that these combination treatments relieved adverse events such as insomnia(risk ratio[RR]=0.20,95%CI:0.06-0.68;P = 0.01)and hive(RR = 0.10;95%CI:0.01-0.73;P = 0.02).Conclusions:The combination of CHMs with a chemical drug like donepezil led to significant improvements in patient cognition as well as a better safety profile when compared to the application of a chemical drug alone.

Alzheimer's diseaseChinese herbal medicinedonepezilmemantinemeta-analysisrandomized controlled trialsrivastigmine

Li Xu、Wen-Jun Chen、Cai-Jun Tian、Yan Zhang、Yan Ma、Tian-Hao Li、Hong-Jie Liu、Zhe Zhang

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Department of the First College English,College of Foreign Language,Shandong University of Traditional Chinese Medicine,Jinan,China

Department of Oncology,Linyi People's Hospital,Linyi,China

Department of Internal Medicine of Traditional Chinese Medicine,The First Clinical College,Shandong University of Traditional Chinese Medicine,Jinan,China

Department of Chinese Materia Medica,College of Traditional Chinese Medicine,Shandong University of Traditional Chinese Medicine,Jinan,China

Department of Medicinal Chemistry,College of Pharmacy,Shandong University of Traditional Chinese Medicine,Jinan,China

Community Healthcare Center,Shenzhen Traditional Chinese Medicine Hospital,Shenzhen,China

Department of Fundamentals of Traditional Chinese Medicine,School of Traditional Chinese Medicine,Jinan University,Guangzhou,China

Shandong Co-Innovation Center of Classic TCM Formula,College of Traditional Chinese Medicine,Shandong University of Traditional Chinese Medicine,Jinan,China

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2019-2020 TCM Technology Development Project of Shandong ProvinceGuangdong Basic and Applied Basic Research FoundationProject of Traditional Chinese Medicine Bureau of Guangdong ProvinceGeneral Program of National Natural Science Foundation of China

2019-00442019A15150106442020107382074306

2024

10.4103/wjtcm.wjtcm_28_23

世界中医药杂志(英文版)
世界中医药学会联合会

世界中医药杂志(英文版)

CSTPCD
ISSN：2311-8571
年,卷(期)：2024.10(1)
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