首页|Babao Dan Inhibits Gastric Cancer Progression in vivo Through Multiple Signaling Pathways

Babao Dan Inhibits Gastric Cancer Progression in vivo Through Multiple Signaling Pathways

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  • 国家科技期刊平台
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Objective:The aim of this study was to explore the effects of Babao dan(BBD),a traditional Chinese medicine,on gastric cancer(GC)progression in vivo.Materials and Methods:A subcutaneous xenograft mouse model of GC was established using MGC80-3 cells.The terminal deoxynucleotidyl transferase-mediated dUTP:2'-deoxyuridine 5'-triphosphate-biotin nick-end labeling method was adopted to detect cell apoptosis in vivo.The expression levels of proteins associated with proliferation,apoptosis,and angiogenesis were measured by immunohistochemical staining or western blotting(WB).The activation and protein levels of p-c-Jun N-terminal kinase(JNK),p-p38,p-extracellular-regulated kinase 1/2,p-nuclear factor-κB(NF-κB),and p-STAT3 were examined by Bio-plex and WB.Results:BBD significantly inhibited tumor growth in GC mouse models with no adverse effect on body weight or organ function.It was also found that BBD significantly suppressed the proliferation of GC tumor cells,induced the apoptosis of tumor cells,and inhibited angiogenesis through inactivating with mitogen-activated protein kinase,NF-κB,and STAT3 pathways.Conclusions:BBD exerts suppressive effects on GC tumor growth by regulating multiple pathways in vivo,which may provide a novel treatment option for GC therapy.

Babao dangastric cancermultiple signaling pathwaysproliferationtraditional Chinese medicine

Hai-Xia Shang、Yi Fang、Bin Guan、Jian-Hua Guan、Jun Peng、Jin-Yan Zhao、Jiu-Mao Lin

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Institute of Oncology of Academy of Integrative Medicine,Fujian University of Traditional Chinese Medicine,Fuzhou,Fujian,China

Key Laboratory of Integrative Medicine of Fujian Province University,Fujian University of Traditional Chinese Medicine,Fuzhou,Fujian,China

Fujian Key Laboratory of Integrative Medicine on Geriatric,Fujian University of Traditional Chinese Medicine,Fuzhou,Fujian,China

Innovation and Transformation Center,Fujian University of Traditional Chinese Medicine,Fuzhou,Fujian,China

Xiamen Traditional Chinese Medicine Co.,Ltd.,Xiamen,Fujian,China

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Natural Science Foundation of Fujian Province,China

2019J01355

2024

10.4103/2311-8571.393751

世界中医药杂志(英文版)
世界中医药学会联合会

世界中医药杂志(英文版)

CSTPCD
ISSN：2311-8571
年,卷(期)：2024.10(1)
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