首页|Evaluating the Compatibility Mechanism of Shengxian Decoction Based on an Excretion Study of 18 Bioactive Constituents in Rat Biosamples

Evaluating the Compatibility Mechanism of Shengxian Decoction Based on an Excretion Study of 18 Bioactive Constituents in Rat Biosamples

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Introduction:The Shengxian decoction(SXT),a Chinese herbal medication used to treat heart failure,is composed of Astragali Radix,Anemarrhenae Rhizoma,Bupleuri Radix,Cimicifuage Rhizoma,and Platycodonis Radix.Knowledge of the excretion of the active compounds in this herbal medication is vital for investigating the underlying mechanisms behind its compatibility.However,this remains unclear.Methods:Liquid chromatography coupled with mass spectrometry was performed in both positive and negative modes to assay 18 constituents of SXT from rat urinary,fecal,and biliary samples.Results:The methodology was validated and showed good linearity(r≥0.9),precision,stability,repeatability,and recovery.The relative standard deviations and relative errors for the precision and accuracy did not exceed 15%.The recoveries of all the compounds ranged from 77.37%to 114.82%,and the matrix effect was between 82.53%and 105.71%.The results suggested that,when combined with Platycodonis Radix,the levels of 14 constituents from the four herbs were reduced in the urine,while the levels of six constituents were reduced in the feces.Conclusions:The comparative excretion results indicated that Platycodonis Radix reduced the excretion of compounds in SXT,demonstrating the compatibility mechanism and holistic properties of these compounds,favoring the pharmacological effects of SXT.

Compatibilityexcretionliquid chromatography coupled with mass spectrometryPlatycodonis RadixShengxian decoction

Tao Pang、Nan Weng、Yong Chen、Cui-Yun Huang、Mei Sun、Feng Zhang、Wan-Sheng Chen

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Department of Pharmacy,Changzheng Hospital,Naval Medical University(Second Military Medical University),Shanghai,China

Department of Pharmacognosy Shenyang Pharmaceutical University,Shenyang,Liaoning Province,China

Traditional Chinese Medicine Resource and Technology Center,Shanghai University of Traditional Chinese Medicine,Shanghai,China

National Key R&D Program of ChinaNational Natural Science Foundation of ChinaScience and Technology Commission of Shanghai MunicipalityOrganizational Key Research and Development Program of Shanghai University of Traditional Chinese Medicine

2022YFC35017008227405922S219019002023YZZ02

2024

10.4103/wjtcm.wjtcm_7_23

世界中医药杂志(英文版)
世界中医药学会联合会

世界中医药杂志(英文版)

CSTPCD
ISSN：2311-8571
年,卷(期)：2024.10(1)
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