首页|Investigating the Potential Mechanism of Huazhi Rougan Granules Against Alcoholic Liver Disease by Network Pharmacology and Experiment

Investigating the Potential Mechanism of Huazhi Rougan Granules Against Alcoholic Liver Disease by Network Pharmacology and Experiment

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  • 国家科技期刊平台
  • NETL
  • NSTL
  • 万方数据
Objective:Huazhi Rougan granules(HRGs)are a promising drug to improve alcoholic liver disease(ALD),but its mechanism remains unclear.Materials and Methods:Network pharmacology,molecular docking,and animal experiments were used to reveal the potential mechanism of HRG against ALD.Results:A total of 245 potential targets of HRG against ALD were obtained.Functional enrichment analysis suggests that HRG could synergistically regulate various biological pathways to exert therapeutic effects on ALD.Molecular docking showed that the key targets exhibited the good binding ability with the key compounds.The in vivo experiments showed that HRG can effectively alleviate pathological changes in liver tissue,improve blood lipid levels,antioxidant stress ability,and liver function,and reduce the release of inflammatory cytokines in the liver.Conclusions:This study reflects that HRG is an effective strategy for treating ALD,providing a basis for revealing the prevention and treatment mechanisms of ALD.

Alcoholic liver diseaseHuazhi Rougan granulesinflammatory responsenetwork pharmacology

Ying-Ying Tan、Ying-Ying Liu、Yi-Yan Zhai、Yi-Xuan Wang、Zhi-Shan Wu、Antony Stalin、Guo-Liang Cheng、Bing Li、Chao Wu、Zhi-Hong Huang、Shan Lu、Xiao-Tian Fan、Zheng Zhao、Jia-Rui Wu

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Department of Clinical Chinese Pharmacy,School of Chinese Materia Medica,Beijing University of Chinese Medicine,Beijing,China

Department of Bioinformatics,Institute of Fundamental and Frontier Sciences,University of Electronic Science and Technology of China,Chengdu,China

Department of Traditional Chinese Medicine,State Key Laboratory of Generic Manufacture Technology of Chinese Traditional Medicine,Linyi,China

Department of Clinical Medicine,Beijing Zest Bridge Medical Technology lnc.,Beijing,China

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2024

10.4103/wjtcm.wjtcm_34_23

世界中医药杂志(英文版)
世界中医药学会联合会

世界中医药杂志(英文版)

CSTPCD
ISSN：2311-8571
年,卷(期)：2024.10(2)