首页|Andrographolide Attenuates Noise-Induced Hearing Loss by Ameliorating Cochlear Inflammation

Andrographolide Attenuates Noise-Induced Hearing Loss by Ameliorating Cochlear Inflammation

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  • 国家科技期刊平台
  • NETL
  • NSTL
  • 万方数据
Objective:This study aimed to explore andrographolide's mechanism of action and its protective effect on noise-induced hearing loss(NIHL).Materials and Methods:A mice animal model for NIHL was established through exposure to broadband noise at 120 dB sound pressure level for 4 h.Transcriptomics analysis and pharmacodynamic experiments were carried out.Results:Andrographolide enters the inner ear and effectively prevents hearing damage following noise exposure in the mice model for permanent hearing loss.Moreover,treatment with andrographolide inhibited the excessive activation of inflammatory factors in the cochleae of noise-exposed mice.Conclusion:Andrographolide might be a promising candidate for auditory protective drug investigation.

Andrographolideanti-inflammatoryauditory protectionnoise-induced hearing losstraditional Chinese medicine compound

Meng-Hua Li、Wan-Qi Wang、Li-Ting Zheng、Meng-Bing Chen、Yang Chu、Miao Qiao、Zuo-Li Zhang、Konduru Naveena、Yong Pan、Yun-Shi Zhang、He Sun、Xiao-Hui Ma、Xi Shi

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Artificial Auditory Laboratory of Jiangsu Province,Xuzhou Medical University,Xuzhou,China

Key Laboratory of Tropical Biological Resources of Ministry of Education,School of Pharmaceutical Sciences,Hainan University,Haikou,China

Department of ENT,Beijing Friendship Hospital,Capital Medical University,Beijing,China

National Key Laboratory of Chinese Medicine Modernization,Tasly Academy,Tasly Pharmaceutical Group Co.,Ltd.,Tianjin,China

Endoscopy Center,Ankang People's Hospital,Ankang,China

Department of Respiratory Medicine,Xuzhou Infectious Diseases Hospital,Affiliated Hospital of Xuzhou Medical University,Xuzhou,China

Department of ENT,The People's Hospital of Rongchang District,Chongqing,China

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Science and Technology Development Aid Project of Xuzhou Science and Technology BureauScience and Technology Development Project of ChongqingHainan Provincial Natural Science Foundation of ChinaTASLY Special Funding 2023Scientific Research Startup Foundation of Hainan University

KC21249CSTB2022NSCQ-M SX1598824MS052

2024

10.4103/wjtcm.wjtcm_60_24

世界中医药杂志(英文版)
世界中医药学会联合会

世界中医药杂志(英文版)

CSTPCD
ISSN：2311-8571
年,卷(期)：2024.10(2)