首页|Glycine Attenuates Myocardial Fibrosis in Myocardial Infarction in Rats Partly through Modulating Signal Transducer and Activator of Transcription 3/Nuclear Factor-κB/Transforming Growth Factor-β axis
Glycine Attenuates Myocardial Fibrosis in Myocardial Infarction in Rats Partly through Modulating Signal Transducer and Activator of Transcription 3/Nuclear Factor-κB/Transforming Growth Factor-β axis
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国家科技期刊平台
NETL
NSTL
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Objective:Inflammation and fibrosis are strongly associated with each other.Glycine is present in various traditional Chinese medicines and exhibits anti-inflammatory activity.However,the effects of glycine on myocardial fibrosis(MF)in rats with myocardial infarction(MI)have not been reported.The purpose of this study is to investigate the effects of glycine therapy on MF and comprehend its underlying mechanisms.Materials and Methods:Left anterior descending artery ligation-induced MI in Sprague Dawley rats was leveraged to assess the therapeutic effects of Glycine.Rats received either normal saline or glycine(0.5 mg/g bodyweight)for 7 days.Results:Glycine upregulated cardiac ejection fraction and fractional shortening to improve cardiac function,as evaluated by echocardiography.Histological and immunohistochemical analyses demonstrated that glycine could decrease inflammatory cell infiltration and alleviate collagen deposition.Western blotting revealed that nuclear factor-κB(NF-κB)-mediated inflammatory signaling was also downregulated by glycine treatment.The expression of signal transducer and activator of transcription 3(STAT3),tumor necrosis factor-α,and transforming growth factor-β(TGF-β)was decreased significantly in the glycine-treated group compared to the model group.Thus,glycine plays a protective role against myocardial ischemia and subsequent MF.Conclusion:The protective effects of glycine were achieved partly through STAT3/NF-κB/TGF-β signaling pathway.
Glycinemyocardial fibrosissignal transducer and activator of transcription 3/nuclear factor-κB/transforming growth factor-β
School of Life Science,Beijing University of Chinese Medicine,Beijing,China
College of Traditional Chinese Medicine,Beijing University of Chinese Medicine,Beijing,China
Modern Research Center of Traditional Chinese Medicine,School of Traditional Chinese Material Medica,Beijing University of Chinese Medicine,Beijing,China
Excellent Youth Foundation of BUCMBeijing Excellent Talent Support Project
国家科技期刊平台
NSTL
万方数据
