Determination of Vinyl Chloride and Vinylidene Chloride Monomer Residues in Medicinal Composite Sheet
The article establishes a headspace gas chromatography method for the determination of vinyl chloride and vinylidene chloride monomer residues in medicinal composite sheet.The separation was performed by HP-INNOWAX capillary column(60 m×0.32 mm×0.5 μm),and hydrogen flame ionization detector was used for testing.Headspace equilibrium temperature was 80℃,equilibrium time was 30 min.The column temperature was 50℃.The split ratio was 10∶1.The inlet temperature was 200℃,and the FID detector temperature was 220℃.The results showed that the linear relationship between vinyl chloride and vinylidean chloride was good(r>0.999)in the range of 0.05~5.0 μg.The average recoveries were 102.1%,101.3%,and the relative standard deviations(RSD)were 1.7%and 1.9%,respectively.The detection limit of vinyl chloride was 0.020 μg/g,and the detection limit of vinylidene chloride was 0.025 μg/g.This method is characterized by its simplicity in operation,accuracy of results,and high sensitivity,and is applicable for the determination of residual vinyl chloride and vinylidene chloride monomer in medicinal composite sheet.
Headspace gas chromatographyMedicinal composite sheetVinyl chlorideVinylidene chloride