Study on the Migration Properties of Ultraviolet Absorbent UV-P in Light-Resistant TPU Infusion Device
This paper established a high performance liquid chromatography(HPLC)method for the determination of ultraviolet absorber UV-P in an light resistant thermoplastic polyurethane infusion device,and to carry out the research on the dissolution of ultraviolet absorber UV-P from disposable TPU infusion device.Six different types of injections were used to simulate the clinical application conditions,and after infusion with a light resistant TPU infusion device,they were analyzed by high-performance liquid chromatography.Kromasil C18 column was adopted,the mobile phase consisted of methanol-water(90∶10),the detection wavelength was 339 nm.The resuls show that calibration curves of UV-P are linear over the range of 0.061 4～1.638 0 mg/L(r=0.999 9),the average recoveries are both betwen 97.91%and 101.10%,the relative standard deviation is less than 2%,the signal-to-noise ratio is greater than 3,and the values of quantitation limit is 0.020 48 mg/L.The method is sensitive and good repeatability,which is suitable for the detection of UV-P dissolution in TPU infusion device.
万方数据
维普
