Objective:To establish a method for the determination of quinolones in hot pot base.Method:Hot pot base sample were extracted by 0.1 mol·L-1 EDTA-Mcllvaine solution,purified by 5%methanol aqueous solution,and analyzed by liquid chromatography-tandem mass spectrometry.Separation was performed using a column SHIMADZU C18 column(2.1 mm×100 mm,3 µm)with 0.1%formic acid-acetonitrile as a mobile phase and gradient elution.The ion source is an electrospray ion source,and the scanning method is positive ion scanning.Result:The method has a good linear relationship,and the correlation coefficient is greater than or equal to 0.99.The recoveries of spiked samples at spiked levels of 1.0～20.0 μg·kg-1 ranged from 65.20%to 110.20%.Conclusion:This method is suitable for the determination of quinolones in hotpot seasonings,which is simple,rapid,sensitive and reproducible.
liquid chromatography-tandem mass spectrometryhot pot basequinolones
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