Determination of Cephalosporin Residues in Pork by UPLC-MS/MS
This article uses ultra high performance liquid chromatography tandem mass spectrometry to analyze the residual levels of cephalosporins in pork.The sample was extracted by acetonitrile aqueous solution and phosphate buffer solution,purified by HLB solid-phase extraction column,and determined by ultra-high performance liquid chromatography mass spectrometry.The results showed that the correlation coefficient(R2)of the three cephalosporin drugs was greater than 0.996 within 0～200 ng·mL-1,indicating a good linear relationship;the detection limit is 0.001～0.365 μg·kg-1,with a quantification limit is 0.003～1.220 μg·kg-1.The spiked recovery rates of samples at different concentrations is 83.2%～95.2%,with a relative standard deviation is 1.9%～7.5%and a standard deviation is 0.078～2.817 μg·kg-1.
porkcephalosporinsultra performance liquid chromatography tandem mass spectrometrysolid-phase extraction column
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