Protective Effect of Curcumin and Selenium-Rich Yeast on Acute Alcoholic Hepatic Injury in Mice
Objective:Exploring the protective effect of curcumin combined with selenium-rich yeast on acute alcoholic liver injury.Method:60 C57B6L/J mice were randomly divided into blank group,model group,curcumin group(33.33 mg·kg-1 bw),selenium-rich yeast group(7.50 mg·kg-1 bw)and combination group(curcumin 33.33 mg·kg-1 bw+selenium-rich yeast 7.50 mg·kg-1 bw),12 mice in each group;30 days after the intervention,a model of acute alcoholic liver injury was established by one-time gavage 50%ethanol solution(12 mL·kg-1 bw);the weight,feeding and behavior changes of mice were observed;liver index and the levels of malondialdehyde(MDA),glutathione(GSH)and triglyceride(TG)were detected,and the histopathological changes of the liver were observed by oil red staining.Result:Compared to control group,the model mice showed liver enlargement,massive accumulation of lipid droplets in liver cells,and significantly increased MDA and TG levels(P＜0.05)in liver tissues,while curcumin combined with selenium-rich yeast could significantly reduce the expression of MDA and TG in the liver,increase the level of GSH(P＜0.05),and reduce the fat deposition in the liver.Conclusion:Curcumin combined with selenium-rich yeast can improve abnormal accumulation of liver lipids induced by acute alcohol gavage,reduce the level of oxidative stress,and have a good protective effect against acute alcoholic liver injury.
万方数据
维普
