Application of Whole Genome Sequencing for the Monitoring Foodborne Salmonella
Salmonella is an important food-borne pathogen that is associated with serious public health and economic implications.With the development of high-throughput sequencing technology,Whole genome sequencing has shown great potential and value in the surveillance of Salmonella.The review strives to discuss the serotype identification,molecular typing and antimicrobial resistance profiles of Salmonella in Whole genome sequence and looks forward to its future.The prediction of serotypes using high-throughput sequencing technology compared with Salmonella antigen-related gene databases plays an important role in cases where serotypes are difficult to determine by serum agglutination methods.Whole genome sequencing technology is faster,higher resolution,and easy to achieve inter-laboratory comparisons than traditional bacterial molecular typing methods,and can be used for rapid identification of pathogens and traceability analysis in public health events.The drug resistance gene database is utilized to discover the drug resistance genes they carry at the gene level,and to explore their resistance mechanisms in conjunction with the drug resistance phenotype.With the continuing maturation of high-throughput sequencing and bioinformatics approaches,and the emergence of more shared database platforms,whole genome sequence analysis will be applied to a wider range of fields.
万方数据
维普
