Rapid Screening and Determination of 56 Antibiotics in Drinking Water by Solid-Phase Extraction Combined with UPLC-MS/MS
Objective:To develop a method for determination of 56 antibiotics in drinking water by solid-phase extraction and UPLC-MS/MS.Method:Drinking water is connected to the solid phase extraction column for purification through a large-capacity sampling tube,target object were separated on C18 with gradient elution using acetonitrile-0.10%formic acid as mobile phase and detected by MS/MS using positive electrospray ionization under the multiple reaction monitoring.Result:The minimum detection of 56 antibiotics was 0.1～2.0 µg·L-1.The correlation coefficients in its linear range are over 0.995.The recovery rates of the 3 concentration levels were 63.3%～113.0%with the relative standard deviations of 3.1%～8.3%.Conclusion:The method has simple and rapid pretreatment,and is suitable for rapid screening and quantitative detection of multiple antibiotics in drinking water.
ultra performance liquid chromatography-tandem mass spectrometrysolid-phase extractiondrinking waterlarge-capacity sampling tube
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