Food Additive Safety Assessment Technology and Its Application
This paper systematically combs the key technologies for safety assessment of food additives,including toxicological assessment methods such as toxicodynamics,toxicence dynamics and omics-based mechanism research,risk assessment strategies such as quantitative structure-activity relationship(QSAR)model,benchmark dosing method and sensitive population and cumulative risk assessment,and emerging assessment technologies such as high-throughput toxicity screening,humanized animal model and physiological toxickinetic modeling.The application of emerging technologies and strategies will greatly expand the scientific connotation of food safety risk assessment,and provide stronger technical support for ensuring dietary safety and human health.
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