The effectiveness of microbial control during food preservation directly affects the quality and safety of food products.However,microbial control in food preservation still faces numerous challenges.This paper,based on a systematic review of factors influencing microbial growth in food preservation,focuses on analyzing key issues such as microbial adaptive evolution under low-temperature storage conditions,induction of resistance due to improper use of chemical preservatives,and cross-contamination caused by packaging technology defects.It proposes targeted microbial control strategies,including optimizing low-temperature storage processes,judicious selection of chemical preservatives,and improving packaging sterilization control,to provide insights for enhancing the quality and safety of food preservation.