Determination of Matrix Effects of Sibutramine Compounds in 6 Common Meal Replacement Foods by HPLC-MS/MS Method
The matrix effects of 6 sibutramine compounds in meal replacement foods were determined by high performance liquid chromatography-tandem mass spectrometry.The results showed that compounds in each of the 6 selected substrates showed moderate matrix effects.Ephedrine showed moderate matrix enhancement effect in milk,chicken breast and cereal.Phenolphthalein showed moderate matrix inhibition effect in cookies,chocolate,plum preserves and cereal.Therefore,if six sibutramine compounds are to be detected at the same time,it is best to use the standard curve with blank matrix extract for quantification,so as to reduce the matrix effect of the corresponding compounds and obtain relatively accurate detection results.
sibutramine compoundsmatrix effect evaluationcommon meal replacementsliquid chromatography-tandem mass spectrometry
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