Determination of Flufenicol and Flufenicol Amine Residues in Dairy Products by Liquid Chromatography-Tandem Mass Spectrometry
Objective:To establish a method for the determination of flufenicol and flufenicol amine residues in dairy products by liquid chromatography-tandem mass spectrometry.Method:Milk samples were extracted with 2%ethyl acetate solution,defatted with n-hexane,then back extracted with 2%ethyl acetate solution,concentrated and tested by machine.Result:The linear relationship between flufenicol and flufenicol amine was good in the range of 1～50 μg·L-1.The limit of detection was 0.5 μg·kg-1,the limit of quantitation was 1 μg·kg-1,the recoveries were 82.5%to 100.4%,and the RSD was 3.35%to 6.98%.Conclusion:The method is suitable for the qualitative and quantitative analysis of flufenicol and flufenicol amide residues in dairy products..
liquid chromatography-tandem mass spectrometrydairy foodflufenicolflufenicol amide
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