Container-Closure Integrity Test of Small-Bottle Instant Probiotic Powder by Vacuum Decay Method
Objective:To establish a vacuum decay method suitable for Container-closure integrity test of small-bottle instant probiotic powder.Method:The vacuum decay method was used to test Container-closure integrity of small-bottle instant probiotic powder packaging.Customized test chambers and negative control samples were prepared,and a flowmeter was used for method development and validation.After validation,the samples were tested.Result:The detection limit of the method was 3 μm,and the linear relationship was good when the leakage flow rate was 0.019～0.816 mL·min-1,and the test accuracy was 100%.Conclusion:The vacuum decay method is easy to operate,highly efficient,and can achieve non-destructive testing.It is suitable for Container-closure integrity test of small-bottle instant probiotic powder.
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