Progress in the Application of Liquid Chromatography-Tandem Mass Spectrometry Pretreatment Technology in the Detection of Nitroimidazoles in Food
Nitroimidazoles have antimicrobial and antiprotozoal effects,but due to the presence of mutagenicity and potential carcinogenicity,some drug species are banned in foods of animal origin.In recent years,in the monitoring and inspection,the phenomenon of excessive nitroimidazole drug residues has occurred from time to time,so the development of rapid,efficient and accurate nitroimidazole drug residue detection methods is of great significance to achieve efficient supervision of nitroimidazole drugs,and then effectively ensure food safety.In this paper,the pretreatment techniques involved in the liquid chromatography-tandem mass spectrometry(LC-MS)detection methods of nitroimidazoles in food are reviewed,the characteristics and advantages of various pretreatment methods are analyzed,and their development directions are prospected.
foodnitroimidazolesliquid chromatography-tandem mass spectrometrypretreatment technology
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