The Ability of Qingxi Black Soft-Shelled Turtle Peptides to Alleviate Leukopenia in Mice
Objective:To explore the ability of Qingxi black soft-shelled turtle peptides(QXBSTPs)to alleviate the decrease in mice.Method:Fifteen SPF grade C57BL/6J male mice were randomly divided into a solvent control group,In the low-dose(2 mg·g-1)administration group,high-dose(4 mg·g-1)administration group,with 5 mice in each group,after 21 days of the intervention,cyclophosphamide was intraperitoneally injected to construct a leukopenia mouse model.The changes of mouse body weight,lesions in the major organs,and the number of leukocytes in the mice were observed.Result:There was no significant difference in body weight between the experimental and the control groups.There were no significant lesions in the major organs between the experimental and control groups.The leukocyte counts of the mice were significantly higher than those of the control group after 24 days of gavage of QXBSTPs at a dose of 4 mg·g-1 daily.Conclusion:Compared with the control group,no significant changes in body weight,no adverse effects and no significant lesions in major organs were observed in the administered group.The administration of QXBSTPs effectively alleviated the reduction of leukocyte number in the mice,and this effect showed a dose-dependent pattern.
Qingxi black soft-shelled turtleQingxi black soft-shelled turtle peptidesleukocytopenia
万方数据
维普
