Ziziphi spinosae Semen is a typical homology of medicine and food material.Modern pharmacological studies have shown that Ziziphi spinosae Semen has a wide range of activities including sedative,hypnotic,anti-inflammatory,antiplatelet and so on,which is widely used in the prevention and treatment of diseases related to nervous,cardiovascular and immune system.Jujuboside,with the characteristics of abundant species and strong biological activity,is one of the important bioactive components of Ziziphi spinosae Semen.In which jujuboside A(JuA)and jujuboside B(JuB)are the main active forms.Recently,studies in China and abroad showed that JuA and JuB have the prominent effects of sedative-hypnotic,cognitive improvement,antidepression and other bioactivities,which could stimulate the application potential of Ziziphi spinosae Semen in food and medicine fields.In order to clarify the mechanism of JuA and JuB exerting biological activities,this paper summarized and evaluated the current research status of JuA and JuB in vivo and in vitro,including metabolic pathways,structure-activity relationship,and their regulatory effects on nervous system in vivo and cells in vitro.Meanwhile,the future research direction of JuA and JuB was proposed,looking forward to provide theoretical reference for the further development and utilization of Ziziphi spinosae Semen.
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