Objective To investigate the uric acid lowering effects of 6 kinds of edible and medicinal resources including honeysuckle,pueraria,lily,coix seed,chicory and turmeric.Methods The target network map of active ingredients was constructed by searching the database of pharmacology analysis of database of pharmacology analysis of traditional Chinese medicine systems,herbal ingredients and target.Serum uric acid(UA),xanthine oxidase(XOD),adenosine deaminase(ADA),blood urea nitrogen(BUN),serum creatinine(Cr),liver XOD and other biochemical parameters in serum of mice were determined.Results According to network pharmacological analysis,the compound contained 44 kinds of active components,among which the core targets were ALB,AKT1 and TNF,and the key pathways were mainly related to glucose and lipid metabolism and inflammation.The results of animal experiments showed that compared with model control group(HUA),serum UA in positive control group(API),medium dose group(FM)and high dose group(FH)was significantly decreased(P＜0.05).The serum ADA in API group,low dose group(FL),FM and FH group was significantly decreased(P＜0.05).In renal indexes,compared with HUA group,Cr level in API group,FL group,FM group and FH group was significantly decreased(P＜0.05).Conclusion This study reveale that the compound may play a role in lowering UA through glucose and lipid metabolism regulation,inflammation inhibition,kidney protection and so on.
关键词
药食同源/网络药理学/尿酸/复方金银花组合物
Key words
edible and medicinal resources/network pharmacology/uric acid/honeysuckle flower compound
维普
万方数据