Objective To evaluate the edible safety of marine aquaculture Monostromanitdum along the coast of Naozhou Island.Methods Using 4 kinds of different collection times of Monostromanitdum as research objects,microwave digestion,inductively coupled plasma mass spectrometry,and atomic fluorescence spectroscopy were used to analyze the content of 5 kinds of heavy metals,Cr,As,Pb,Hg,and Cd,in Monostromanitdum samples,and microbial indicators were determined.Using acute oral toxicity experiments on mice,the food safety of Monostromanitdum was evaluated by analyzing indicators such as drinking water,diet,body weight,organ coefficient,mortality rate,and appearance of mice.Results The content of Cr,As,Pb,and Hg in the sample far exceeded the food safety content specified by the national standard,with the maximum being 29.20,12.12,3.59 and 3.70 times the limit values,respectively.The total number of bacterial colonies in the samples exceeded 50 CFU/g.The mice in the group administered with Monostromanitdum by gavage showed signs of death,with organ coefficients increasing in all organs except for the liver,and the appearance changes consistent with heavy metal poisoning.Conclusion There are safety risks associated with consuming unprocessed Monostromanitdum,and the safety of direct consumption is relatively low.