In order to optimize the extraction process of arecoline from byproduct areca core by low temperature subcritical technology,on the basis of single factor experiment,arecoline extraction yield was selected as the index,the liquid-solid ratio,extraction temperature and extraction time were selected for response surface optimization test design,and the optimal process parameters were determined.The results showed that the optimal extraction parameters were as follows:extraction time 40 min,liquid-solid ratio 9∶1(mL/g),extraction temperature 47 ℃,and extraction times 4.Under above condition,the yield of oil extract was 1.2%,and the extraction yield of arecoline was 4.46 mg/g by HPLC detection.The optimum technological parameters for extraction of arecoline from byproduct areca core by low temperature subcritical technology were obtained.These parameters are stable,reliable and useful,which can provide reference for the development of areca-nut resources.