Study the Effect of L-Carnitine Chlorogenic Acid Tablets on Anti-obesity of Rats
Study the effect of tablets(L-camitine chlorogenic acid tablets)on anti-obesity of high-fat diet-induced-obese rats.Five groups were established.They were blank control group,obesity model group,low-dose group 0.17 g/kg Bw,middle-dose group 0.33 g/kg Bw and high-dose group 1.00 g/kg Bw,respectively.Each group had ten male SD rats.The blank controlgroup was treated with basal fed by gavage;The model group was fed with high-fat diet;Three tablet treated groups were fed with high-fat diet and administered with corresponding the dosage of tabletsby gavage;All treatment were lasted for consecutive 42 d.Several indexes were detected in respect of body weight,body weight gained,food intake,total calorie intake,food utilization rate,body fat weight,and the ratio of fat weight to body weight to evaluate its effect on anti-obesity.The results showed that high-fat diet-obese models were induced successfully.Compared with the model group,final body weight gained 228.7±19.1 g,total food utilization rate was 19.6％±1.6％,body fat weight was 31.94±4.73 g,the ratio of fat weight to body weight was 5.68％±0.81％,the final body weight gained 191.4±28.3 g,total food utilization rate was 17.4％±1.8％,body fat weight was 22.69±6.93 g,and the ratio of fat weight to body weight(4.27％±1.06％)of high-dose group was significantly lower(P＜0.05).Compared with model group,there were no significant difference in total food intake and total calorie intake among the rats in each dose group(P＞0.05).Based on the experimental condition,L-carnitine chlorogenic acid tablets have anti-obese effect on diet-induced obese rats.
L-camitinethe extract of Eucommia ulmoides leafthe extract of lotus leafSD ratsanti-obesity
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