Pterostilbene is a methylated derivative of resveratrol with higher bioavailability than resveratrol.Pterostilbene has wide-ranging health benefits and applications because of its anti-tumor,antioxidant,and anti-inflammatory properties.The production of pterostilbene mainly includes plant extraction,chemical synthesis,and microbial synthesis.Plant extraction of pterostilbene is relatively safe but suffers from low extraction efficiency and product purity.Chemical synthesis of pterostilbene offers high efficiency,but involves the high cost of purifying by-products and environmental pollution.Microbial synthesis of pterostilbene is environmentally friendly,but has drawbacks such as low conversion efficiency and potential safety concerns.Therefore,optimizing different methods and establishing an efficient and environmentally friendly production method for pterostilbene remains a hot topic in research in this field.Focus on various methods and research progress of pterostilbene production,providing insights into future directions.It aims to serve as a reference for relevant research of pterostilbene production.