Dietary Intervention Improves Lipid Metabolism Abnormalities and Organ Damage in Obese Mice Induced by High-Fat Diet
The aim of this study was to explore the effects of dietary intervention on mice with high-fat diet.The typical weight-loss dishes in the Meal Manager platform of Hisense AiJia APP were represented,including chicken breast salad,sauteed kale,vegetable salad,and sauteed greens with mushrooms.The effects of these weight loss recipe foods on body weight,lipid metabolism and inflammatory factors were assessed by long-term intake in high-fat diet mice.The results showed that the dietary intervention could effectively inhibit high-fat diet-induced obesity in mice,in which the sauteed green with mushroom group and sauteed kale group significantly reduced the body weight and organ index of high-fat diet mice(P＜0.05).In addition,the dietary intervention improved dyslipidemia in high-fat diet mice,reducing serum levels of total cholesterol(TC),triglycerides(TG),and low-density lipoprotein cholesterol(LDL-C),while increasing serum levels of high-density lipoprotein cholesterol(HDL-C).The results of H&E staining and ELISA indicated that the dietary intervention attenuated high-fat diet-induced attenuated high-fat diet-induced colon-and liver-associated inflammation,and that the sauteed green with mushroom group and sauteed kale group not only inhibited high-fat diet-induced liver and small intestinal injury,but also significantly reduced tumor necrosis factor-α(TNF-α),interleukin-6(IL-6),and interleukin-1β(IL-1β)levels in the liver(P＜0.05).These results could provide some theoretical support and optimization suggestions for dietary intervention in treating chronic obesity.
万方数据
维普
