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黑果枸杞花青素微胶囊的稳定性及靶向释放特性

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以黑果枸杞花青素微胶囊在水相体系中花青素的保留率为指标,采用控制变量法研究了环境因素温度、循环冻融、自然光照、紫外光照对花青素稳定性的影响,进一步研究了花青素的氧化降解规律;采用体外模拟胃肠液的方法对花青素微胶囊的稳定性和靶向释放特性进行了研究.结果表明:花青素微胶囊的热降解符合一级降解动力学模型;微胶囊化花青素在低温和低pH条件下较稳定,光照能够降低花青素的稳定性.在体外模拟胃肠液稳定性实验中,花青素微胶囊在胃液中比肠液中稳定,与未包埋花青素溶液相比,花青素微胶囊溶液在模拟胃液中其花青素的保留率提高了14.8%,在模拟肠液中提高了17.3%;在体外模拟胃肠液靶向释放实验中,在胃液中,90 min后,花青素微胶囊溶液和花青素未包埋溶液中花青素的释放率分别为7.5%、20.7%;在肠液中花青素缓慢释放,240 min后,二者花青素的释放率分别为21.9%、27.2%;并且花青素微胶囊后能够显著提高其在水相体系中的稳定性,起到在胃肠液中缓释的效果.
Stability and targeting release characteristics of anthocyanin microcapsules of Lycium ruthenicum Murr
The retention rate of anthocyanin in aqueous phase system was evaluated with anthocyanin microcapsules of Lycium ruthenicum Murr,the effects of environmental factors such as temperature,cyclic freezing and thawing,light and uv on the stability of anthocyanidins in Lycium ruthenicum Murr were investigated.The oxidative degradation of anthocyanins was further studied.The stability and targeting release characteristics of anthocyanin microcapsules were studied by in vitro simulated gastrointestinal solution.And the results showed it was first order reaction kinetics model.The low temperature and low pH were better for the stability of microencapsulated anthocyanins,light could reduce the stability of anthocyanins.In vitro simulation of gastrointestinal fluid stability test,anthocyanin microcapsules were stable in simulated gastric fluid than in the intestinal fluid,the retention rates of anthocyanin microcapsules in simulated gastric fluid were increased by 14.8% and 17.3% in simulated intestinal fluid,compared with the unencapsulated anthocyanin solution.In vitro simulated gastrointestinal fluid targeted release test,Anthoeyanin release rate was 7.5% and 20.7% in anthocyanin microcapsule solution and anthocyanin solution after 90 min in the simulated gastric fluid.Anthocyanins were released slowly in simulated intestinal fluid,release rate were 21.9% and 27.2% respectively after 240 min.Moreover,anthocyanin microcapsules could improve significantly their stability in aqueous phase systems and play a slow-release effect in the gastrointestinal fluid.

Lycium ruthenicum Murranthocyaninsmicrospheresstabletarget release

陈虎、吴晓梅、李悦、杭园园、曹得霞、李希羽、王树林

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青海大学农牧学院,青海西宁810016

青海大学省部共建三江源生态与高原农牧业国家重点实验室,青海西宁810016

黑果枸杞 花青素 微胶囊 稳定性 靶向释放

青海省科技厅高新技术研究与发展计划

2015-GX-201A

2018

食品工业科技
北京一轻研究院

食品工业科技

CSTPCD北大核心
影响因子:0.842
ISSN:1002-0306
年,卷(期):2018.39(1)
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