基于文献计量分析药食同源物质缓解酒精性肝损伤研究进展
Research Progress on the Alleviation of Alcoholic Liver Injury Based on Bibliometric Analysis of Medicinal and Food Homologous Substances
向琴 1张国泰 1芦润青 1唐菁雯 1贺思桥 1闵聪 1耿敬章1
作者信息
- 1. 陕西理工大学生物科学与工程学院,陕西省资料生物重点实验室,陕南秦巴山区生物资源综合开发协同创新中心,秦巴生物资源与生态环境重点实验室,陕西汉中 723000
- 折叠
摘要
目的:分析药食同源物质缓解酒精性肝损伤相关领域的研究现状及热点内容,为学者对药食同源物质缓解酒精性肝损伤的深入研究提供思路.方法:采用文献计量学方法,以CNKI、WOS及PubMed数据库为文献源,对自建库起至 2022年 12月药食同源物质缓解酒精性肝损伤研究领域文献的分布情况进行检索和分析.结果:共检索药食同源物质缓解酒精性肝损伤的中英文文献 418篇,专利 276项.国内该领域研究起步较晚,但发展速度快,且发文量及专利数量均高于国外,发文量呈指数型结构上升,专利量呈线性结构上升;研究热点主要为葛根、枳椇子、枸杞等药食同源物质缓解酒精性肝损伤的作用机制研究.结论:通过分析药食同源物质缓解酒精性肝损伤文献及专利现状,系统总结了酒精性肝损伤的发病机制,主要与乙醇代谢、氧化应激、免疫炎症反应及肠道屏障受损和菌群失调相关;药食同源物质缓解酒精性肝损伤的作用机制主要与抗脂质过氧化、抗氧化应激反应、抗炎作用及清除自由基、调节肠道菌群有关;未来该领域将以网络药理学、组学技术等技术手段进行更深入的机制研究.
Abstract
Objective:This paper analyze the research status and hot contents in the field related to alleviating alcoholic liver injury by medicinal and food homologous substances,and provided ideas for researchers to further in-depth study their alle-viation effects on alcoholic liver injury.Methods:By using the bibliometric method,the CNKI,WOS and PubMed datab-ases as the literatures source,the distribution of literatures in the field of alleviating alcoholic liver injury from the estab-lishment of the library to 2022 were searched and analyzed.Results:A total of 418 Chinese and English literature and 276 patents on alleviating alcoholic liver injury with drugs and food homologous substances were obtained.Domestic research in this field started late,but its development speed was fast,and the number of domestic publications and patents were higher than that of foreign countries.The trends in the number of publications and patents showed exponential and linear increase,respectively.The research hotspots mainly focused on the effect mechanism of Kudzu,Hovenia dulcis Thunb.,Goji berry and other medicinal and food homologous substances in alleviating alcoholic liver injury.Conclusion:By analyzing the research status of the literature and patent,the pathogenesis of alcoholic liver injury was systematically summary,mainly relate to the ethanol metabolism,oxidative stress,immune inflammatory response and impaired intestinal barrier and dysbacteriosis.The influencing mechanism of medicinal and food homologous substances in alleviating alcoholic liver injury was mainly related to anti-lipid peroxidation,oxidative stress response,anti-inflammatory effect,scavenging of free radicals,and regulation of intestinal flora.In the future,this field would be further studied in the mechanism by network pharmacology,histological techniques and other methods.
关键词
药食同源物质/酒精性肝损伤/文献/研究现状/发病机制/作用机制Key words
medicinal and food homologous substances/alcoholic liver damage/literature/research status/pathogenesis/mechanism引用本文复制引用
基金项目
秦巴生物资源与生态环境国家重点实验室(培育)"市校共建"专项(SXC-2106)
陕西省教育厅重点科学研究计划项目(23JY018)
陕西省秦创原"科学家+工程师"队伍建设项目(2023KXJ-203)
陕西理工大学秦巴食品资源开发利用科技创新团队科研专项()
陕西理工大学研究生创新基金(SLGYCX2317)
出版年
2024
国家科技期刊平台
NSTL
万方数据